COVID-19: A promising cure for the global panic.
Identifieur interne : 000903 ( Main/Exploration ); précédent : 000902; suivant : 000904COVID-19: A promising cure for the global panic.
Auteurs : Balachandar Vellingiri [Inde] ; Kaavya Jayaramayya [Inde] ; Mahalaxmi Iyer [Inde] ; Arul Narayanasamy [Inde] ; Vivekanandhan Govindasamy [Inde] ; Bupesh Giridharan [Inde] ; Singaravelu Ganesan [Inde] ; Anila Venugopal [Inde] ; Dhivya Venkatesan [Inde] ; Harsha Ganesan [Inde] ; Kamarajan Rajagopalan [Inde] ; Pattanathu K S M. Rahman [Royaume-Uni] ; Ssang-Goo Cho [Corée du Sud] ; Nachimuthu Senthil Kumar [Inde] ; Mohana Devi Subramaniam [Inde]Source :
- The Science of the total environment [ 1879-1026 ] ; 2020.
Abstract
The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.
DOI: 10.1016/j.scitotenv.2020.138277
PubMed: 32278175
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">COVID-19: A promising cure for the global panic.</title><author><name sortKey="Vellingiri, Balachandar" sort="Vellingiri, Balachandar" uniqKey="Vellingiri B" first="Balachandar" last="Vellingiri">Balachandar Vellingiri</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India. Electronic address: geneticbala@buc.edu.in.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Jayaramayya, Kaavya" sort="Jayaramayya, Kaavya" uniqKey="Jayaramayya K" first="Kaavya" last="Jayaramayya">Kaavya Jayaramayya</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Iyer, Mahalaxmi" sort="Iyer, Mahalaxmi" uniqKey="Iyer M" first="Mahalaxmi" last="Iyer">Mahalaxmi Iyer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Narayanasamy, Arul" sort="Narayanasamy, Arul" uniqKey="Narayanasamy A" first="Arul" last="Narayanasamy">Arul Narayanasamy</name><affiliation wicri:level="1"><nlm:affiliation>Disease Proteomics Laboratory, Department of Zoology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Disease Proteomics Laboratory, Department of Zoology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Govindasamy, Vivekanandhan" sort="Govindasamy, Vivekanandhan" uniqKey="Govindasamy V" first="Vivekanandhan" last="Govindasamy">Vivekanandhan Govindasamy</name><affiliation wicri:level="1"><nlm:affiliation>Farmer's Bio Fertilizers and Organics, Coimbatore 641 029, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Farmer's Bio Fertilizers and Organics, Coimbatore 641 029, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Giridharan, Bupesh" sort="Giridharan, Bupesh" uniqKey="Giridharan B" first="Bupesh" last="Giridharan">Bupesh Giridharan</name><affiliation wicri:level="1"><nlm:affiliation>Virology Laboratory, Central Research and Development Wing, Sree Balaji Medical College and Hospital (SBMCH), Bharath University, (BIHER), Chromepet, Chennai 600044, Tamil Nadu, India; Department of Forest Science, Central University of Nagaland, Lumami, Zunhebeto, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Virology Laboratory, Central Research and Development Wing, Sree Balaji Medical College and Hospital (SBMCH), Bharath University, (BIHER), Chromepet, Chennai 600044, Tamil Nadu, India; Department of Forest Science, Central University of Nagaland, Lumami, Zunhebeto</wicri:regionArea><wicri:noRegion>Zunhebeto</wicri:noRegion></affiliation></author><author><name sortKey="Ganesan, Singaravelu" sort="Ganesan, Singaravelu" uniqKey="Ganesan S" first="Singaravelu" last="Ganesan">Singaravelu Ganesan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Thiruvalluvar University, Vellore 632115, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Thiruvalluvar University, Vellore 632115</wicri:regionArea><wicri:noRegion>Vellore 632115</wicri:noRegion></affiliation></author><author><name sortKey="Venugopal, Anila" sort="Venugopal, Anila" uniqKey="Venugopal A" first="Anila" last="Venugopal">Anila Venugopal</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Venkatesan, Dhivya" sort="Venkatesan, Dhivya" uniqKey="Venkatesan D" first="Dhivya" last="Venkatesan">Dhivya Venkatesan</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Ganesan, Harsha" sort="Ganesan, Harsha" uniqKey="Ganesan H" first="Harsha" last="Ganesan">Harsha Ganesan</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Rajagopalan, Kamarajan" sort="Rajagopalan, Kamarajan" uniqKey="Rajagopalan K" first="Kamarajan" last="Rajagopalan">Kamarajan Rajagopalan</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Rahman, Pattanathu K S M" sort="Rahman, Pattanathu K S M" uniqKey="Rahman P" first="Pattanathu K S M" last="Rahman">Pattanathu K S M. Rahman</name><affiliation wicri:level="1"><nlm:affiliation>Deploy Lead - Centre for Enzyme Innovation, Office No: 6.06, King Henry Building School of Biological Science, University of Portsmouth, Portsmouth PO1 2DY, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deploy Lead - Centre for Enzyme Innovation, Office No: 6.06, King Henry Building School of Biological Science, University of Portsmouth, Portsmouth PO1 2DY</wicri:regionArea><wicri:noRegion>Portsmouth PO1 2DY</wicri:noRegion></affiliation></author><author><name sortKey="Cho, Ssang Goo" sort="Cho, Ssang Goo" uniqKey="Cho S" first="Ssang-Goo" last="Cho">Ssang-Goo Cho</name><affiliation wicri:level="3"><nlm:affiliation>Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kumar, Nachimuthu Senthil" sort="Kumar, Nachimuthu Senthil" uniqKey="Kumar N" first="Nachimuthu Senthil" last="Kumar">Nachimuthu Senthil Kumar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, Mizoram University (A Central University), Aizawl 796 004, Mizoram, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biotechnology, Mizoram University (A Central University), Aizawl 796 004, Mizoram</wicri:regionArea><wicri:noRegion>Mizoram</wicri:noRegion></affiliation></author><author><name sortKey="Subramaniam, Mohana Devi" sort="Subramaniam, Mohana Devi" uniqKey="Subramaniam M" first="Mohana Devi" last="Subramaniam">Mohana Devi Subramaniam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai 600 006, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai 600 006</wicri:regionArea><wicri:noRegion>Chennai 600 006</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:32278175</idno><idno type="pmid">32278175</idno><idno type="doi">10.1016/j.scitotenv.2020.138277</idno><idno type="wicri:Area/PubMed/Corpus">000219</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000219</idno><idno type="wicri:Area/PubMed/Curation">000219</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000219</idno><idno type="wicri:Area/PubMed/Checkpoint">000715</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000715</idno><idno type="wicri:Area/Ncbi/Merge">003898</idno><idno type="wicri:Area/Ncbi/Curation">003898</idno><idno type="wicri:Area/Ncbi/Checkpoint">003898</idno><idno type="wicri:Area/Main/Merge">000903</idno><idno type="wicri:Area/Main/Curation">000903</idno><idno type="wicri:Area/Main/Exploration">000903</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">COVID-19: A promising cure for the global panic.</title><author><name sortKey="Vellingiri, Balachandar" sort="Vellingiri, Balachandar" uniqKey="Vellingiri B" first="Balachandar" last="Vellingiri">Balachandar Vellingiri</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India. Electronic address: geneticbala@buc.edu.in.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Jayaramayya, Kaavya" sort="Jayaramayya, Kaavya" uniqKey="Jayaramayya K" first="Kaavya" last="Jayaramayya">Kaavya Jayaramayya</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Iyer, Mahalaxmi" sort="Iyer, Mahalaxmi" uniqKey="Iyer M" first="Mahalaxmi" last="Iyer">Mahalaxmi Iyer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore 641 043, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Narayanasamy, Arul" sort="Narayanasamy, Arul" uniqKey="Narayanasamy A" first="Arul" last="Narayanasamy">Arul Narayanasamy</name><affiliation wicri:level="1"><nlm:affiliation>Disease Proteomics Laboratory, Department of Zoology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Disease Proteomics Laboratory, Department of Zoology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Govindasamy, Vivekanandhan" sort="Govindasamy, Vivekanandhan" uniqKey="Govindasamy V" first="Vivekanandhan" last="Govindasamy">Vivekanandhan Govindasamy</name><affiliation wicri:level="1"><nlm:affiliation>Farmer's Bio Fertilizers and Organics, Coimbatore 641 029, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Farmer's Bio Fertilizers and Organics, Coimbatore 641 029, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Giridharan, Bupesh" sort="Giridharan, Bupesh" uniqKey="Giridharan B" first="Bupesh" last="Giridharan">Bupesh Giridharan</name><affiliation wicri:level="1"><nlm:affiliation>Virology Laboratory, Central Research and Development Wing, Sree Balaji Medical College and Hospital (SBMCH), Bharath University, (BIHER), Chromepet, Chennai 600044, Tamil Nadu, India; Department of Forest Science, Central University of Nagaland, Lumami, Zunhebeto, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Virology Laboratory, Central Research and Development Wing, Sree Balaji Medical College and Hospital (SBMCH), Bharath University, (BIHER), Chromepet, Chennai 600044, Tamil Nadu, India; Department of Forest Science, Central University of Nagaland, Lumami, Zunhebeto</wicri:regionArea><wicri:noRegion>Zunhebeto</wicri:noRegion></affiliation></author><author><name sortKey="Ganesan, Singaravelu" sort="Ganesan, Singaravelu" uniqKey="Ganesan S" first="Singaravelu" last="Ganesan">Singaravelu Ganesan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Zoology, Thiruvalluvar University, Vellore 632115, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Zoology, Thiruvalluvar University, Vellore 632115</wicri:regionArea><wicri:noRegion>Vellore 632115</wicri:noRegion></affiliation></author><author><name sortKey="Venugopal, Anila" sort="Venugopal, Anila" uniqKey="Venugopal A" first="Anila" last="Venugopal">Anila Venugopal</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Venkatesan, Dhivya" sort="Venkatesan, Dhivya" uniqKey="Venkatesan D" first="Dhivya" last="Venkatesan">Dhivya Venkatesan</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Ganesan, Harsha" sort="Ganesan, Harsha" uniqKey="Ganesan H" first="Harsha" last="Ganesan">Harsha Ganesan</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Rajagopalan, Kamarajan" sort="Rajagopalan, Kamarajan" uniqKey="Rajagopalan K" first="Kamarajan" last="Rajagopalan">Kamarajan Rajagopalan</name><affiliation wicri:level="1"><nlm:affiliation>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Human Molecular Cytogenetics and Stem Cell Laboratory, Department of Human Genetics and Molecular Biology, Bharathiar University, Coimbatore 641 046, Tamil Nadu</wicri:regionArea><wicri:noRegion>Tamil Nadu</wicri:noRegion></affiliation></author><author><name sortKey="Rahman, Pattanathu K S M" sort="Rahman, Pattanathu K S M" uniqKey="Rahman P" first="Pattanathu K S M" last="Rahman">Pattanathu K S M. Rahman</name><affiliation wicri:level="1"><nlm:affiliation>Deploy Lead - Centre for Enzyme Innovation, Office No: 6.06, King Henry Building School of Biological Science, University of Portsmouth, Portsmouth PO1 2DY, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Deploy Lead - Centre for Enzyme Innovation, Office No: 6.06, King Henry Building School of Biological Science, University of Portsmouth, Portsmouth PO1 2DY</wicri:regionArea><wicri:noRegion>Portsmouth PO1 2DY</wicri:noRegion></affiliation></author><author><name sortKey="Cho, Ssang Goo" sort="Cho, Ssang Goo" uniqKey="Cho S" first="Ssang-Goo" last="Cho">Ssang-Goo Cho</name><affiliation wicri:level="3"><nlm:affiliation>Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul, South Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kumar, Nachimuthu Senthil" sort="Kumar, Nachimuthu Senthil" uniqKey="Kumar N" first="Nachimuthu Senthil" last="Kumar">Nachimuthu Senthil Kumar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biotechnology, Mizoram University (A Central University), Aizawl 796 004, Mizoram, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Biotechnology, Mizoram University (A Central University), Aizawl 796 004, Mizoram</wicri:regionArea><wicri:noRegion>Mizoram</wicri:noRegion></affiliation></author><author><name sortKey="Subramaniam, Mohana Devi" sort="Subramaniam, Mohana Devi" uniqKey="Subramaniam M" first="Mohana Devi" last="Subramaniam">Mohana Devi Subramaniam</name><affiliation wicri:level="1"><nlm:affiliation>Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai 600 006, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Genetics and Molecular Biology, Vision Research Foundation, Chennai 600 006</wicri:regionArea><wicri:noRegion>Chennai 600 006</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Science of the total environment</title><idno type="eISSN">1879-1026</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The novel Coronavirus disease 2019 (COVID-19) is caused by SARS-CoV-2, which is the causative agent of a potentially fatal disease that is of great global public health concern. The outbreak of COVID-19 is wreaking havoc worldwide due to inadequate risk assessment regarding the urgency of the situation. The COVID-19 pandemic has entered a dangerous new phase. When compared with SARS and MERS, COVID-19 has spread more rapidly, due to increased globalization and adaptation of the virus in every environment. Slowing the spread of the COVID-19 cases will significantly reduce the strain on the healthcare system of the country by limiting the number of people who are severely sick by COVID-19 and need hospital care. Hence, the recent outburst of COVID-19 highlights an urgent need for therapeutics targeting SARS-CoV-2. Here, we have discussed the structure of virus; varying symptoms among COVID-19, SARS, MERS and common flu; the probable mechanism behind the infection and its immune response. Further, the current treatment options, drugs available, ongoing trials and recent diagnostics for COVID-19 have been discussed. We suggest traditional Indian medicinal plants as possible novel therapeutic approaches, exclusively targeting SARS-CoV-2 and its pathways.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>Inde</li><li>Royaume-Uni</li></country><region><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Inde"><noRegion><name sortKey="Vellingiri, Balachandar" sort="Vellingiri, Balachandar" uniqKey="Vellingiri B" first="Balachandar" last="Vellingiri">Balachandar Vellingiri</name></noRegion><name sortKey="Ganesan, Harsha" sort="Ganesan, Harsha" uniqKey="Ganesan H" first="Harsha" last="Ganesan">Harsha Ganesan</name><name sortKey="Ganesan, Singaravelu" sort="Ganesan, Singaravelu" uniqKey="Ganesan S" first="Singaravelu" last="Ganesan">Singaravelu Ganesan</name><name sortKey="Giridharan, Bupesh" sort="Giridharan, Bupesh" uniqKey="Giridharan B" first="Bupesh" last="Giridharan">Bupesh Giridharan</name><name sortKey="Govindasamy, Vivekanandhan" sort="Govindasamy, Vivekanandhan" uniqKey="Govindasamy V" first="Vivekanandhan" last="Govindasamy">Vivekanandhan Govindasamy</name><name sortKey="Iyer, Mahalaxmi" sort="Iyer, Mahalaxmi" uniqKey="Iyer M" first="Mahalaxmi" last="Iyer">Mahalaxmi Iyer</name><name sortKey="Jayaramayya, Kaavya" sort="Jayaramayya, Kaavya" uniqKey="Jayaramayya K" first="Kaavya" last="Jayaramayya">Kaavya Jayaramayya</name><name sortKey="Kumar, Nachimuthu Senthil" sort="Kumar, Nachimuthu Senthil" uniqKey="Kumar N" first="Nachimuthu Senthil" last="Kumar">Nachimuthu Senthil Kumar</name><name sortKey="Narayanasamy, Arul" sort="Narayanasamy, Arul" uniqKey="Narayanasamy A" first="Arul" last="Narayanasamy">Arul Narayanasamy</name><name sortKey="Rajagopalan, Kamarajan" sort="Rajagopalan, Kamarajan" uniqKey="Rajagopalan K" first="Kamarajan" last="Rajagopalan">Kamarajan Rajagopalan</name><name sortKey="Subramaniam, Mohana Devi" sort="Subramaniam, Mohana Devi" uniqKey="Subramaniam M" first="Mohana Devi" last="Subramaniam">Mohana Devi Subramaniam</name><name sortKey="Venkatesan, Dhivya" sort="Venkatesan, Dhivya" uniqKey="Venkatesan D" first="Dhivya" last="Venkatesan">Dhivya Venkatesan</name><name sortKey="Venugopal, Anila" sort="Venugopal, Anila" uniqKey="Venugopal A" first="Anila" last="Venugopal">Anila Venugopal</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Rahman, Pattanathu K S M" sort="Rahman, Pattanathu K S M" uniqKey="Rahman P" first="Pattanathu K S M" last="Rahman">Pattanathu K S M. Rahman</name></noRegion></country><country name="Corée du Sud"><region name="Région capitale de Séoul"><name sortKey="Cho, Ssang Goo" sort="Cho, Ssang Goo" uniqKey="Cho S" first="Ssang-Goo" last="Cho">Ssang-Goo Cho</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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